Friday 24 August 2012

Newly discovered genetic markers could signal colon cancer development

ScienceDaily (Aug. 23, 2012) ? University of Minnesota Medical School and Masonic Cancer Center researchers have partnered with geneticists from Genentech, Inc., to discover how some proteins may cause the development of some forms of colon cancers.

The proteins -- part of R-spondin family -- normally help activate cell proliferation during embryonic development. Now, University of Minnesota researchers have discovered that when two types of R-spondins -- RSPO2 and RSPO 3 -- are reactivated in adults through certain gene mutations, they can signal cells to restart the cell proliferation process, which can lead to tumor growth in the colon.

The discovery, which involved multiple researchers from the University's Masonic Cancer Center, could lead the way to more personalized colon cancer therapy designed around the genetics of a patient's specific cancer. The results are available online now, in the journal Nature.

"These results suggest there is a potential for personalized therapies based on knowing a tumor's specific genetics," said David Largaespada, Ph.D., associate director of Basic Sciences and professor in the Department of Genetics, Cell Biology and Development. "And because these R-spondins are related to embryonic growth, and seem to not have major roles in the adult, targeting them would likely be low in side effects."

To arrive at the results, researchers analyzed more than 70 pairs of human colon tumors and a mouse model engineered using the Sleeping Beauty transposon by Largaespada. Through a series of investigations, researchers identified 36 rearrangements that result in gene fusions, including two recurrent ones involving R-spondin family members RSPO2 and RSPO3.

While the results could generate more personalized approaches to the treatment of colon cancer, researchers stress more research is needed before these results can be applied to actual patient care.

Caitlin Conboy, an M.D./Ph.D. student studying at the University of Minnesota, worked closely on this project and is nowworking to advance the science of this paper to the next stage.

"What we're finding is that tumors may look the same, but they're fundamentally different," said Conboy. "Diagnosis may be less about the tissue where the tumor is found, like the breast or colon, but the drivers of the tumor's growth."

Conboy is beginning work on a study that will help determine if a blocking agent could be useful in treating tumors driven by R-spondin production. If this project is successful, it could help create new therapeutic approaches useful in certain patients after a tumor genetic test is done.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Minnesota Academic Health Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Somasekar Seshagiri, Eric W. Stawiski, Steffen Durinck, Zora Modrusan, Elaine E. Storm, Caitlin B. Conboy, Subhra Chaudhuri, Yinghui Guan, Vasantharajan Janakiraman, Bijay S. Jaiswal, Joseph Guillory, Connie Ha, Gerrit J. P. Dijkgraaf, Jeremy Stinson, Florian Gnad, Melanie A. Huntley, Jeremiah D. Degenhardt, Peter M. Haverty, Richard Bourgon, Weiru Wang, Hartmut Koeppen, Robert Gentleman, Timothy K. Starr, Zemin Zhang, David A. Largaespada, Thomas D. Wu, Frederic J. de Sauvage. Recurrent R-spondin fusions in colon cancer. Nature, 2012; DOI: 10.1038/nature11282

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/zupl9SdFnmA/120824093515.htm

tony robbins abraham lincoln vampire hunter their eyes were watching god lara logan manu ginobili sports illustrated swimsuit 2012 aretha franklin whitney houston

Medical Travel Club : Q&A ? Answers Archive ? One Hour Payday ...

Loan for Dss-a customized financial option by Sam Miller
1888 Articles Home | Finance Articles | Loans Articles | Online Business Articles Loans RSS One Hour Payday Loans Grab Funds Within No Time!
One hour payday loans are just the perfect answer to all your troubles that crop up without giving any prior warning. No documentation and no faxing make the entire loan application procedure simple yet quick.

Other Related Articles

Loans for Bad Credit ? Instant Monetary Relief by Tom Dikkin

One Hour Payday Loans Grab Funds Within No Time! by Dennison Williams

Form Good Habits of Running by Steven Cherrys

Resolving ?The document name?? Word Error by Jameshraider

Payday 2day ? avail cash for urgent purposes by Keith Gonzalez

Dennison Williams is a well known author and has been writing content for same day payday loans . His content is worth reading as it gives you an insight about different aspects of no fax payday loans and same day payday loans. Please visit For more information

Article Source:

About Author
Author: Dennison Williams Article Tools: If you are stuck in middle month crisis and looking for a way out then one hour payday loans are the way to go. The concept of such loans was unthinkable a few years ago. However,Chaussures Louboutin, now they exist to cater to all your short-term needs. Getting this loan is extremely convenient as there are several lenders who offer this amazing facility availing which you can live a stress free life. Once you have applied for this loan you can be assured of getting funds within no time. Financial market of the United Kingdom has crafted this amazing loan facility for its residents. Availing these loans you can overcome all your troubles within the shortest time possible.

As the very name suggests,louboutin, funds through this loan can be availed within a maximum duration of one hour. You no more have to wait for even a day to avail funds. As a matter of fact, lenders and brokers who sanction this loan do not ask you for the details and purpose for which you are applying for loans you have complete liberty to spend the acquired cash as per your need and wish. You can utilize the availed amount to pay for electricity bills,ralph lauren pas cher, storage bills, grocery bills, credit card bills, weekly petrol bills, organize a party or even buy a new computer,Christian Louboutin, television or car. The call is yours.

Applying for a this amazing loan facility is extremely easy and time-saving. Online mode of appliance is quick. It just takes your precious few minutes to fill-up the online loan application form. If you have a broadband connection at home or workplace, you can apply for loans right away.

First, select the lender who fits your budget. Chances are that you might come across several lenders who offer this loan at an extremely competitive interest rate and repayment terms and conditions. Fill up the application form with right and complete details. They will then verify the information provided by you and would deposit cash into your validated bank account.

You can apply for this loan despite having an appalling credit history. Unlike traditional mode of application where an applicant has to undergo credit substantiation process,Ralph Lauren Pas Cher, here no such checks are conducted. This makes the entire procedure quick. Even those tagged with defaults,ralph lauren pas cher, insolvency,ralph lauren france, foreclosures, bankruptcy, individual voluntary arrangements, late or skipped payments, county court judgments or bankruptcy can apply for this loan without thinking much. Besides, non homeowners and tenants are also eligible to apply for one hour payday loans. ???????? Moving Becomes Easier With Professional Movers Washington Company Article ? Business Articles Even more people Payday Loans An Essential Evil! Article ? Business Articles Ralph Lauren Pas Cher

Source: http://www.medicaltravelclub.com/qa/2012/08/one-hour-payday-loans-grab-funds-within-no-time-article-finance-loans-article/

nfl schedule 2012 andrew shaw christina aguilera tupac hologram pulitzer prize winners nfl 2012 schedule

Zlantan: RT @MarioBaloltelli: BREAKING: Victor Moses announces his retirement from first team football at the young age of 21! #Benched

Sorry, Readability was unable to parse this page for content.

Source: http://twitter.com/Zlantan/statuses/238706168250392577

columbine British Open leaderboard Jessica Ghawi askew People Water Fred Willard Emmy nominations 2012

Sunday 19 August 2012

Guidance On How To Approach Significant Back Pain ? Articles. All ...

[unable to retrieve full-text content]Guidance On How To Approach Significant Back Pain. August 18, 2012 | Author: VidanaOlivar213 | Posted in Health & Fitness. Back pain attacks numerous people and can range between a light irritation to some significantly crippling issue.

Source: http://www.twenty4seven365.com/2012/08/18/guidance-on-how-to-approach-significant-back-pain/

ncaa brackets 2012 odd lamar d antoni fashion star andrew bird lizzie borden

Nancy Pelosi Settles Fruit By The Foot vs. Fruit Roll-Up Debate On 'Fallon' (VIDEO)

When Jimmy Fallon slaps on a pair of Serious Newsman Glasses, that can only mean one thing: It's time for "Night News Now" on "Late Night with Jimmy Fallon." On Friday's episode, he welcomed guest correspondent, um, Rep. Nancy Pelosi (?!) to settle an important debate raging in cafeterias across America: Which is better, Fruit by the Foot or Fruit Roll-Ups?

It's probably the only time you'll hear Pelosi say the word "snackage" on network TV. Also, we love that she pronounces "Mario Kart" exactly how you think she would.

Keep an eye out for another correspondent played by Isiah Whitlock Jr., who portrayed Clay Davis on "The Wire." Was Nancy Pelosi fraternizing with Sen. Davis backstage? Shieeeet.

Also on HuffPost:

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2012/08/18/nancy-pelosi-settles-fruit-by-the-foot-debate-on-fallon_n_1803419.html

viktor bout ncaa hockey role models ferdinand porsche gregg williams theraflu masters leaderboard

Who needs Melky? Giants piling up hits, runs, wins

Associated Press Sports

updated 11:58 p.m. ET Aug. 18, 2012

SAN DIEGO (AP) - The San Francisco Giants have responded well to being without their top offensive player.

Playing their third game without suspended outfielder Melky Cabrera, the Giants cranked up their offense and used another big inning in an 8-7 win over the San Diego Padres on Saturday night.

Joaquin Arias homered and drove in three runs, Hunter Pence had two RBIs and Buster Posey had three hits and one of San Francisco's three sacrifice flies.

"That's what it takes, guys picking each other up," Giants manager Bruce Bochy said.

San Francisco has scored 22 runs on 37 hits in three games since Cabrera was suspended on Wednesday for 50 games following a positive test for testosterone.

Arias hit a leadoff homer in the second and had an RBI single to cap a four-run fifth that put the Giants ahead 5-4. He blooped an RBI single in the seventh when San Francisco scored twice to take a 7-5 lead.

"It's fun to see our offense work," said Pablo Sandoval, who had two hits and drove in a run. "When you have guys coming through in RBI situations, I'm happy for that."

The Giants followed up the 15 hits they had in Friday night's 10-1 win over San Diego, when they broke loose for an eight-run inning, with 14 more on Saturday.

"It was a good win for us, good comeback," said Bochy. "The guys had another big inning to save us."

San Francisco remained in first place in the NL West by a half-game over the Los Angeles Dodgers, 6-2 winners over Atlanta.

San Diego lost despite getting a three-run homer from Chase Headley and Carlos Quentin's solo shot. The Padres have dropped five straight games and have lost 19 of their last 25 meetings with the Giants.

"It's been nice to hit a couple of homers," Headley said. "You try to focus on wins and losses. When you don't win, it really doesn't matter to you."

Headley reached the 20-homer mark for the first time in his career. The switch-hitter leads the majors in August with eight home runs and 24 RBIs.

Jose Mijares (1-0) retired the only two batters he faced to pick up the win. Jeremy Affeldt allowed two runs in the ninth before Clay Hensley got the final out for his third save.

Giants starter Barry Zito lasted only four innings before getting pulled for a pinch-hitter leading off the fifth. Zito allowed four runs and six hits.

"I knew I had a fresh bullpen and we needed to get back in the game," Bochy said about lifting Zito while trailing, 4-1.

Zito is 1-2 with a 7.37 ERA in his last five starts. At Petco Park, he is 0-3 with a 7.28 ERA in his last six starts.

"I wasn't frustrated with him," Zito said. "I was frustrated I wasn't more aggressive."

Brad Brach (1-3) allowed two runs and four hits with a walk, retiring just one batter.

San Diego's Eric Stults couldn't hold a 4-1 lead. He gave up five runs and nine hits over six innings.

Headley contributed to the Giants' four-run inning with a questionable defensive play.

Pinch-hitter Ryan Theriot led off with a single and went to third on Angel Pagan's double. Marco Scutaro followed with a sacrifice fly. Pablo Sandoval then hit a grounder to Headley's left at third base.

As Headley fielded the ball, he had to make a 360-degree spin. Instead of going to first, the off-balanced Headley decided to throw home in an attempt to get Pagan. But the throw had little zip on it, and Pagan scored easily.

"Obviously, I wish I would have made the throw to first, now," Headley said.

Posey doubled and Sandoval soon scored on Pence's sacrifice fly. Arias then singled in the final run.

NOTES: The Padres scored more runs against San Francisco than they had in losing their previous four games, when they were outscored 28-2. ... Zito is 1-7 in his last 12 starts against the Padres. This was the first time in that stretch that he received more than two runs of support. ... It appears likely that Padres opening-day starter Tim Stauffer is done for the season. Stauffer, who made only one start, has been on the DL with a strained right elbow virtually all season. The right-hander is considering surgery to repair a flexor tendon. ... San Francisco has won 11 of its last 15 road games since the All-Star break, outscoring its opponents by a 110-50 margin. ... San Francisco RHP Ryan Vogelsong (10-6, 2.72 ERA), coming off his worst start of the season, opposes LHP Clayton Richard (9-12, 3.91) in the series finale Sunday.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


advertisement

More newsGetty Images
Thrice as nice for Dodgers

Hanley Ramirez drove in four runs with two homers, including the first of three straight shots by the Los Angeles Dodgers in the second inning Saturday night during a 6-2 win over the Atlanta Braves.

Source: http://nbcsports.msnbc.com/id/48715290/ns/sports-baseball/

telenav wade phillips wade phillips time person of the year sag nominations sag nominations time magazine person of the year

Wednesday 15 August 2012

Exclusive interview of Aleksandar L.Grujic ? Professional Trader ...

Our first interview received incredible feedback from our readers so we thought it was high time we brought you a new one. Without further delay, let?s hear from one of GCI?s most valued Business Partners: Aleksandar L.Grujic. Alex has been actively trading with us since 2003. He has also developed a unique Trading Strategy on Crude Oil and GOLD which we will detail further in the second part of the interview.

Alex, can you tell us when and why you started trading Forex?
In the past it was my regular practice for a few years to convert currencies between my bank accounts and benefit from the fluctuations of their exchange rates. I used to convert USD to DEM or CHF to GBP and wait for the exchange rate to move in my favor.
I had a good bank?s exchange rate with tight spreads and was quite happy with this process?
Until a day came that I transferred most of my money in USD and the currency started its multi-month drop and even multiyear weakness later on. I got very upset with this and realized that I wasn?t knowledgeable enough in my decisions making process (I relied on my intuition and banker?s advices) so I started searching the web in panic to learn more about currencies. It is then that I first heard of the ?online trading? concept and I took my first Forex course in 2003.
It was this year as well that I first heard of GCI Financial. The idea of Forex trading seemed very exciting and I was sure I would find something really beneficial in this story!

Trading since 2003? So Alex you are a very experienced trader today and I imagine you have been building a solid trading strategy throughout the years. Could you describe it in a few lines?
My Trading Strategy (TS) is a professional document which coherently links together a set of carefully defined profit-making opportunities, market patterns, trading rules, mental attitudes and money management in order to generate profits. Following a robust TS blindly is the only way to succeed in making profits consistently.
Overcoming the usual market fears is also an essential part of my TS and it consists of 12 very important points. Accepting and handling internet and platform limitations seems to be extremely useful so this is part of my TS document as well. The most important component of my TS is related to winning mindset attitudes and behaviors. And I have two different strategies, one for short-term trading (intraday swings) and another one for daily/weekly trading. I find most success when applying my TS on EUR/USD, GBP/USD, USD/CHF, USD/CAD, Crude Oil, Gold and SMI. This document called TS is so important that I dedicated many hours in presenting it professionally in my ?Mastering the Art of Currency Trading? specialized trading educational course.

This is quite an important tip you are giving for to traders: Build a solid trading strategy and stick to it while working on managing ?market fears?.

Alex, for all the beginners reading this interview but also for the more experienced traders that are also interested in your trading strategy could you please explain which technical indicators you use the most and why?
I use RSI, SMA, support/resistance lines, candle patterns, false moves before important news announcements, Fibo lines and few other proprietary indicators. The most important point with any indicator is for one to choose all variables of this indicator (by backtesting) with an absolute precision so that it can generate profits on a large sample. No indicator can predict the market moves with 90-100% rate of success, but as long as it generates signals that in total of at least 30 trades give profits, then I consider it successful.

Thank you Alex!

This concludes the first part of our interview with Alexander Grujic. Check back soon for part 2 for exclusive tips and beginner?s advice from this experienced and successful trader. Alex will also be telling us why he chose to trade with GCI and we will detail his ?Mastering the Art of Currency Trading? specialized trading educational course as well.

This entry was posted in Trader Interviews. Bookmark the permalink.

Source: http://blog.gcitrading.com/forex-trader-interviews/exclusive-interview-of-alexander-grujic-introducing-broker-and-trader-since-2003.htm?utm_source=rss&utm_medium=rss&utm_campaign=exclusive-interview-of-alexander-grujic-introducing-broker-and-trader-since-2003

tom watson kawasaki disease resurrection masters tickets one direction tulsa news scalloped potatoes

Thursday 9 August 2012

Choosing Effective Plans Of Payday Loan Finance ... - ShowBed.com

07 August

Author: PetruccelliSjodin349 ?/ ?Category: Uncategorized

Payday loans can be very tricky to understand, especially if you have never taken one out before. However, getting a payday loan is way easier for people who have gone online, done the proper investigation and learned what exactly these loans entail. Below, a list of crucial advice for payday loan customers is listed.

Use payday loans only for cash emergencies. One of the benefits of a payday loan is that it allows you to remain self-sufficient and handle your own finances in private. If you had to borrow the money from family or friends, then you would need to disclose your financial situation, which many people prefer to keep to themselves.

Understand what a payday loan is. A payday loan is a high-interest loan for a short time period. These are typically completed with one trip to the payday loan office. In exchange for practically instant cash, you need to write out a check to the payday lender for the value of the loan, plus the interest expense, and any fees. The lender cashes this check at some agreed-upon future date, usually one, or two weeks.

The best tip available for using payday loans is to never have to use them. If you are struggling with your bills and cannot make ends meet, payday loans are not the way to get back on track. Try making a budget and saving some money so you can avoid using these types of loans.

If you feel even a little uncomfortable with the payday loan you are applying for, stop what you are doing. There are many companies that are scaming people, and you need to feel one-hundred percent comfortable with what you are doing. You will be the one responsible for paying this loan back, so make sure that you know exactly what you are getting into.

Limit your use of payday loans to emergency situations. It can be difficult to repay such high-interest rates on time, leading to a negative credit cycle. Do not use payday loans to purchase unnecessary items, or as a means to securing extra cash flow. Avoid using these expensive loans, to cover your monthly expenses. Visit Why Not Check Here for well-rounded recommendations.

It is important not to use payday loans to pay for luxury items, such as TV?s or vacations. They are best used in cases where there is an emergency or a bill you cannot pay on time. If you need money for luxury items it is better to look for a loan from your bank or a low-interest credit card. The interest charged on this type of credit will always be less than a payday loan.

Never rely on payday loans consistently if you need help paying for bills and urgent costs, but remember that they can be a great convenience. As long as you do not use them regularly, you can borrow payday loans if you are in a tight spot. Remember these tips and use these loans to your advantage!

Take a look at our site for intelligent guidance: pressexposure.com/Curt_Cloyd-443682.html and direct marketing trends ? what?s needed.

Source: http://showbed.com/uncategorized/2012/08/07/choosing-effective-plans-of-payday-loan-finance-resources/

johnny damon kirk cameron news 10 hillary rosen j.k. rowling j.k. rowling axl rose

Saturday 4 August 2012

Pro-gay marriage groups plan Chick-fil-A 'Kiss-In'

Pro-gay marriage groups plan protests against the national chain, while supporters of Chick-fil-A burst into patriotic song in a viral YouTube video. NBCNews.com's Dara Brown reports.

By Martha C. White, NBC News contributor

Updated 3:40 p.m. ET: Two days after supporters of Chick-fil-A president Dan Cathy's stance against gay marriage flocked to its restaurants for an Appreciation Day, pro-gay marriage advocates are descending on the fast-food chain with a message of their own.?

"We want to show Chick-fil-A and the country that the LGBT community's love is just as valid, just as good as heterosexual love," said grassroots advocate Carly McGehee.

McGehee started "National Same-Sex Kiss Day at Chick-fil-A" at which she said same-sex couples are encouraged to visit the chain, "have a quick smooch or hug or show of affection," then post a photo or video of it online. She said organizers of local kiss-ins have been told to suggest that participants take their pictures outside the restaurants by its signs to avoid violating trespassing ordinances.?

More than 13,000 people have signed up as "attending" on the event's Facebook page.?

"This is not just about gay people getting together and kissing in front of a restaurant," said Marci Alt, an activist who organized a kiss-in at a Chick-fil-A in suburban Atlanta at noon?(many of the others are scheduled for 8:00 p.m.). Yesterday, Alt posted a Change.org petition asking Cathy to have dinner with her, her wife and two kids, which had collected around 1,300 signatures by Friday.

Alt said roughly 100 protesters were gathered by 11:30 a.m., half an hour before the event was set to begin, and that the crowd fluctuated between 50 and 100 people for the first hour. She characterized the gathering as "very peaceful" although there was a police presence of four officers, along with a single counter-protester.

The restaurant was serving "typical lunch hour traffic," Alt said.

The group didn't receive any hostility from patrons or employees, Alt said. In fact, "[workers] brought two trays of lemonade out" for people protesting in the 95-degree heat. "It was very nice of them," Alt said, adding that they turned down the beverages.

"It really seems like this is a way young people on social media are responding to Dan Cathy," Rich Ferraro, spokesperson for the Gay and Lesbian Alliance Against Defamation, said.

An NBC affiliate in the Los Angeles area reported Friday that vandals had defaced a Chick-fil-A restaurant in?Torrance, depicting a cow with a paint can alongside?the words "Tastes Like Hate" in an uneven block-letter font, mimicking the one used by the company in its ads.

Related story: Chick-fil-A protest marks rise of 'eat-in' movement

The firestorm kicked off after Cathy's interview in the Baptist Press last month, when the chicken scion said he was "guilty as charged" for opposing same-sex marriage. Through its foundation arm, family-owned Chick-fil-A has a long history of donating to organizations that oppose gay marriage. It?also embraces other evangelical principles like closing its restaurants on Sundays.?

Wednesday's Chick-fil-A Appreciation Day, launched on Facebook by former Arkansas governor Mike Huckabee, had more than 668,000 people listed as "attending." It could have earned the chain an additional $8 million in revenue, according to one analyst's estimate. Privately held Chick-fil-A wouldn't provide numbers but said it was a record day for sales. Local news outlets across the country reported long lines and police directing traffic at restaurants across the country.

Despite the sizable grassroots support, Chick-fil-A has faced backlash from other sectors. Lawmakers in Boston, Chicago and Philadelphia voiced objection to the company building new restaurants in their cities, and the toy company run by the estate of Muppet creator Jim Henson said it will no longer make toys for the restaurant's kids' meals. (Chick-fil-A has said it decided to stop selling the Henson toys a day prior to that decision.)

"This is about, 'I should have the same rights as everybody else,'" Alt said.?

Source: http://bottomline.nbcnews.com/_news/2012/08/03/13104208-pro-gay-marriage-groups-plan-chick-fil-a-kiss-in?lite

mario balotelli mario balotelli jenny mccarthy michael jackson espn3 kevin youkilis Tropical Storm Debby